Departemen Klinik, Fakultas Kedokteran Universitas Ciputra

Abstrak

Cleft lip (CL) is a congenital abnormality in which there is a cleft in the lip under the ala nasi and if it extends to the ceiling it is called a cleft lip palate (CLP). The cause of non-syndromic CLP is DNA damage. This paper aims to determine the differences in level of DNA damage in non-syndromic CL and CLP patients. The method used is colorimetric ELISA using blood samples of CL and CLP patients at the CLP center of the Faculty of Medicine, University of Muhammadiyah Malang. Total samples obtained was 44 samples with 12 samples from non-syndromic CL patient and 32 samples from non-syndromic CLP patient. The results showed that the level of DNA damage did not show a significant difference (unpaired t test, p = 0.378) in non-syndromic CL and CLP patients.